A Method for Understanding The Life History of Cells: MEMOIR

A recent study within the journal Nature has provided proof of principle for a novel technique that allows the encoding of a cell’s history in its genome and the subsequent readout of the information. known as MEMOIR (Memory by engineered mutagenesis with Optical in situ Readout), the new technique provides insight into cellular patterns of communication, relationships between cells, and various alternative events of influence, reaching on the far side the static view of cells that’s typically obtained.

In the current study, researchers used two tools to trace changes within the cellular genome. sequential single molecule light in place hybridization (seqFISH) provides insight into that specific genes are active during a specific cell. The second technique, the currently notable CRISPR, facilitates genome editing via a deoxyribonucleic acid slicing system. Together, the 2 tools were wont to produce a novel order memory storage element, very like a computer bit, that has two distinct states and might be assessed for shared CRISPR edits using seqFISH and microscopy.

DNA cell lineage trailing provides necessary info about cell and tissue development, as well as that of abnormal tissues like tumors. although this study used MEMOIR to trace the cellular history of murine embryonic stem cells over many generations, the technique has the potential to supply insight into cell lineages across several generations, as well as tissue development and historical cellular events. Future applications might include the tracking of many signal pathways in individual cells as well as for the study of tumorigenesis and metastases.

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